Pim1 and p27
WebJul 31, 2002 · Pim1 and Gfi1 insertions occurred with similar frequencies in p27−/− and p27+/+ mice (Table 1). Neither the total number of viral insertions per tumor nor the frequency of CIS such as Gfi1 and Pim1 was increased in the p27−/− lymphomas, indicating that p27 loss does not accelerate lymphomagenesis by increasing the total number of … WebJul 31, 2002 · The p27 Kip1 protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human …
Pim1 and p27
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WebFeb 4, 2024 · PIM1 phosphorylates serine-112 at higher rate, while serine-136 and serine-155 at lower rate . PIM2 predominantly phosphorylates serine-112 [65,66]. PIM3 … WebDec 10, 2014 · Morishita et al. have demonstrated that phosphorylation of p27 by Pim kinases prompts its binding to 14–3–3 proteins and subsequent nuclear exclusion and degradation of p27. Furthermore, Pim kinases seem to down-regulate p27 at the transcriptional level by inactivating Forkhead transcription factors [ 53 ].
WebJun 12, 2014 · PIM1 kinase is overexpressed in many tumor types including lymphomas and prostate cancer, where it is known to cooperate with the MYC oncogene in promoting tumorigenicity. PIM1 has emerged as an attractive target for drug discovery, but few PIM1 inhibitors have been tested in vitro or in vivo. WebOncogenic Pim-1 kinase is upregulated in multiple solid cancers, including human pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with few useful …
Web描述了降解剂‑抗体缀合物(DAC)，该降解剂‑抗体缀合物包含抗TM4SF1抗体及其抗原结合片段。所述的降解剂分子包含泛素E3连接 ... WebApr 29, 2024 · 9. The method of claim 1, wherein the compound inhibits catalytic activity of PIM1, PIM2, PIM3, or combinations thereof. ... PIM kinases activate cdc25A/C, while repressing p21 and p27, to regulate cell cycle, and they also facilitate the formation of ABCB1 and ABCG2 efflux pumps which generate drug resistance. PIM kinases have been ...
WebPralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis. Targets. DHFR [1] In vitro. Pralatrexate and bortezomib exhibits concentration- and time-dependent cytotoxicity against a broad panel of T-lymphoma cell lines.
WebJul 1, 2008 · The levels of p27 Kip1 protein (Fig. 6A,, bottom, left) and p27 Kip1 mRNA (Fig. 6A,, bottom, right) were both down-regulated in K562/wt-Pim1S cells although they … alo 45WebNational Center for Biotechnology Information alo68WebApr 15, 2024 · PIM1 is thought to promote the carcinogenesis by cooperating with myc. PIM1 inhibitor upregulated p27 expression and nuclear accumulation, consequently … alo51WebApr 29, 2024 · PIM kinases are constitutively active proto-oncogenic serine/threonine kinases that play a role in cell cycle progression, metabolism, inflammation and drug resistance. PIM kinases interact with and stabilize p53, … aloa547l242WebSep 1, 2024 · 1. Introduction. Cervical cancer is a malignant epithelial tumor formed in the cervix. However, because screening programs in many parts of the world are not perfect, … alo4 chemieWebRegulation of PIM-1 kinase activities. Structural analysis revealed that the PIM-1 protein contains a constitutively active kinase conformation that does not require to be phosphorylated for activation. 17 This means that the level of PIM-1 enzymatic activity in a cell is dependent on the absolute amount of protein present. Typically, both PIM-1 mRNA … alo6是几面体Web“p27mt对裸鼠肝癌移植瘤侵袭性生长的影响”出自《肿瘤防治研究》期刊2010年第10期文献，主题关键词涉及有p27mt、肝癌、裸鼠、生长、侵袭等。钛学术提供该文献下载服务。 alo accreditation