Cyp4a14基因

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Web百度百科是一部内容开放、自由的网络百科全书，旨在创造一个涵盖所有领域知识，服务所有互联网用户的中文知识性百科全书。在这里你可以参与词条编辑，分享贡献你的知识。 WebBackground/aims: Cyp4a14 is a member of cytochrome P450 (Cyp450) enzyme superfamily that possesses NADPH monooxygenase activity, which catalyzes omega-hydroxylation of medium-chain fatty acids and arachidonic acid. Study suggests that down-regulation of Cyp4a14 has an anti-inflammatory response in intestine. The present study was to test …

内质网应激蛋白在Cyp4a14基因敲除小鼠肠炎模型中的表达及意义

Web基因沉默产品通常由3-5段长度为19-25nt的核苷酸序列组成; 如果需要研究针对CYP4A14基因单个靶点的siRNA产品的沉默效率，可以申请购买单条siRNA产品。获取 si/shRNA 基因 … WebMar 5, 2024 · Predicted to enable heat shock protein binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in brain; embryo; liver; and lung. portland area agency on aging

The cytochrome P450 4 (CYP4) family - PubMed

WebCYP4A 抗体 E-6 是小鼠单克隆 IgG 1 κ， CYP4A抗体, 在 13篇文献中引用，规格为 200 µg/ml. 免疫原氨基酸序列301-507位于mouse物种的CYP4A的C-terminus. CYP4A 抗体 (E … WebDECEMBER 23, 2004 VA DIRECTIVE 5383 7. g. Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71, 101 Stat. 391, 468-471, codified at Title 5 … WebApr 12, 2024 · 近日，清华大学自动化系汪小我团队与美国斯坦福大学统计系王永雄团队合作提出自动归纳基因调控序列编码模式的神经网络解释方法。该方法针对广泛应用于基因 … portland area auto wrecking yards

CYP4A14 siRNA (m), shRNA and Lentiviral Particle Gene …

WebMar 9, 2024 · CYP4A14 may represent a useful target for the treatment of AngII-associated renal damage. this study provides a link between CYP4A14 and NAFLD. Overexpression … WebThe Burn is a news and lifestyle website primarily focused on restaurants, retail, shopping centers, entertainment venues and other topics that have people buzzing in Loudoun … optical outlet golden gate flWebFeb 20, 2015 · VA Directive 6518 4 f. The VA shall identify and designate as “common” all information that is used across multiple Administrations and staff offices to serve VA … portland area apartments

"Web1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both mammals and insects. 2. The CYP4A … " - Cyp4a14基因

Cyp4a14基因

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WebJan 1, 2012 · Cyp4a14基因缺失可以减轻软脂酸诱导的肝细胞脂质沉积，其机制可能与Cyp4a14代谢产物19-HETE介导的肝细胞脂肪酸摄取减少有关。Cyp4a14可能成为治疗脂肪肝和肝纤维化的潜在的药物靶标。本课题共发表文章4篇，SCI论文2篇（其中1篇已提交至Hepatology，为本领域顶尖SCI ... Webcyp3a4诱导物和抑制剂目录（仅为常用药物） cyp3a4的抑制剂可根据其效力进行分类，例如：强抑制剂是引起血浆auc值至少增加5倍或清除率降低80％以上的抑制剂。. 中度抑制剂 …

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Web4.Cyp4a14基因促使小鼠IL-1β,IL-6和TNF-α mRNA在结肠中的表达高于肝脏组织,肝脏组织中促炎分子的增加可能是通过肝肠循环由肠道炎症反应而来. 5.未发现NADPH氧化 …

Web这个基因，cyp1a1，编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。这种蛋白质定位于内质网，其表达是由一些多环芳烃（pahs）诱导的，其中一些存在于香烟烟雾中。该酶的内源底物尚不清楚，但它能将一些多环芳烃代谢为致癌 WebCyp4A14高水平的表达在小鼠肾脏近端小管,其功能异常与高血压的发生存在密切联系。目前研究发现小鼠Cyp4A14基因缺失与人Cyp4A11的基因突变均可引起原发性高血压。本文就Cyp4A14在肾脏中的分布、功能以及其与高血压发生的关系作一综述。

Web内质网应激蛋白在Cyp4a14基因敲除小鼠肠炎模型中的表达及意义. 背景:炎症性肠病 (inflammatory bowel disease,IBD)是一种肠道的慢性非特异性炎症性疾病,其病因还未明确.内质网应激 (endoplasmic reticulum stress,ERS)参与多种疾病的发病机制,包括IBD.Cyp4a14是一种肝脏产生的与 ... WebTo further determine the role of CYP4A14 in hepatic lipid metabolism, we fed wild-type and CYP4A14 gene knockout (cyp4a14 −/−) mice with a high-fat diet for 2 mo. Compared with HFD-fed wild-type mice, cyp4a14 −/− …

WebA novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997 Aug 1;325(Pt 3):741-9. Latest. J:272457 Gilani A, et al., High-fat diet-induced obesity and insulin resistance in CYP4a14(-/-) mice is mediated by 20-HETE. Am J Physiol Regul Integr Comp Physiol. 2024 Nov 1 ...

WebAug 8, 2024 · More importantly, potent expression of CYP4A was detected in liver tissues from NAFLD patients, and CYP4a14−/− mice were resistant to hepatic steatosis and fibrosis . Therefore, unravelling the roles of CYP4A in the pathogenesis of hepatic steatosis and developing methods to target CYP4A may be a valuable approach to treating human … portland area audi dealershipsWeb目的:随着人们生活水平的提高,我国非酒精性脂肪肝的发病率越来越高.本文旨在探讨细胞色素P450ω-羟化酶CYP4A14在肝脏脂质代谢中的作用,以期为阐明非酒精性脂肪肝发生的机制提供线索.方法: (1)野生型 (WT)及CYP4A14基因敲除 (4A14KO)小鼠分为如下四组:1)WT+普通饮 … portland area bike shopsWeb下载此文档内质网应激介导果糖诱发的小鼠肝脏SREBP-1c激活与脂质沉积.pdf 文档分类：论文页数：约19页举报非法文档有奖 portland area banksWebFKBP51基因敲除线粒体高脂饮食肥胖 ... 利用Real-time PCR技术,对测序结果筛选出的相关分子GCK、Cyp21al、Cyp4a10、Cyp4a14在mRNA水平的进行验证;5)电镜观察线粒体:通过电镜观察RD WT、HF WT、RDKO及HFKO四组小鼠的肝脏组织并拍照,利用软件对每组线粒体的面积进行测量,并 ... portland area boats for saleWebMar 3, 2024 · CYP4A14 deficiency ameliorated MCD-induced steatohepatitis and liver injury. Male wild-type (WT) littermates and cyp4a14 −/− mice were fed with an ND (normal diet) or MCD diet for 4 wk. (A) Oil Red O staining showing that cyp4a14 −/− mice were resistant to MCD-induced lipid accumulation in the livers. (Magnification: 200×.) portland area attractionsWeb其中,srebp-1c是调控肝脏fa和tg合成有关基因的主要转录因子,与肝细胞内tg的过度蓄积产生脂肪毒性和胰岛素抵抗(ir)的发生密切相关。 ... 、c钾4aio、cyp4a14和cypzei mrna的表达水平。方法:肝匀浆总rna提取采用trizol试剂一步提取法, p工pcr逆转录cdna合成按gibcobrl公 … portland area air qualityWeb2 days ago · 为什么要做基因检测？在一些电影中，我们经常看到这样的桥段：坏人无论逃到哪里，最后都能被找到并绳之于法，这离不开比打车软件更靠谱的 ... optical outlet in lady lake fl