WebConcanamycin A will also affect both PRF1 and GZMB release. Irrespective of the mechanism underlying this effect, these results indicate that GZMB may exert the same … WebNitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Exp. Ther.

Concanamycin A, the specific inhibitor of V-ATPases, …

WebConcanamycin A is a plecomacrolide antibiotic that has been found in Streptomyces. 1 It is active against S. cerevisiae, S. sake, A. citri, P. citrinum, and P. oryzae (MICs = <0.39, <0.39, <0.39, 1.56, and 25 μg/ml, respectively). Concanamycin A inhibits vacuolar H + -ATPase (V-ATPase; EC 50 = ~2.1-2.3 μM). 2 It also decreases perforin levels ... WebJul 29, 2024 · Concanamycin A, also designated folimycin, is an antibiotic and well-noted specific inhibitor of V-ATPase (vacuolar type H +-ATPase) activity. Concanamycin A is … crawford house perth

Concanamycin A counteracts HIV-1 Nef to enhance immune …

WebATPase) exhibited high sensitivity to concanamycin A, with an IC50 of 0.002 x 10-3 µmol/mg. Concanamycin A has 20 times the inhibitory effect on the V-type ATPase compared to bafilomycin A1.2 Its inhibition of vacuolar type H+ ATPase has been studied,3 and compared with the effects of bafilomycin in inducing apoptotic cell death. The family of Webconcanamycin (plural concanamycins) Any of a group of antibiotics extracted from the gut of the tobacco hornworm Retrieved from " … Concanavalin A (ConA) is a lectin (carbohydrate-binding protein) originally extracted from the jack-bean (Canavalia ensiformis). It is a member of the legume lectin family. It binds specifically to certain structures found in various sugars, glycoproteins, and glycolipids, mainly internal and nonreducing terminal α-D … See more Like most lectins, ConA is a homotetramer: each sub-unit (26.5kDa, 235 amino-acids, heavily glycated) binds a metallic atom (usually Mn and a Ca ). It has the D2 symmetry. Its tertiary structure has been elucidated, as have … See more ConA and its variants (found in closely-related plants) are the only proteins known to undergo a post-translational sequence arrangement known as Circular permutation in proteins whereby the N-terminal half of the conA precursor is swapped to … See more Concanavalin A interacts with diverse receptors containing mannose carbohydrates, notably rhodopsin, blood group See more • Concanavalin+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Concanavalin+A+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more dji goggles connect to phantom 4