Cisplatin potassium wasting

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August undefined, 2024

WebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, … WebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced …

Renal salt wasting in patients treated with high-dose cisplatin ...

WebMay 24, 2006 · Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the … WebOne way your body regulates blood potassium levels is by shifting potassium into and out of cells. When there is a breakdown or destruction of cells, the electrolyte potassium moves from inside of the cell to outside of the cell wall. This shift of potassium outside of the cells causes hyperkalemia. orangeville water treatment

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and … Webis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion … orangeville waste schedule

Protective Effect of Magnesium Preloading on Cisplatin-induced ...

WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as … WebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … ipl 2023 csk player listWebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … orangeville water treatment plant

"WebApr 1, 2024 · The patient’s laboratory values on admission He was admitted to the hospital and received a total of 230 mmol of potassium intravenously and by mouth over the next 20 hours, but his serum potassium level increased to only 2.9 mmol/L. Therefore, the nephrology service was consulted to evaluate his refractory hypokalemia. " - Cisplatin potassium wasting

Cisplatin potassium wasting

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebCisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m 2) and etoposide (100 mg/m 2) therapy. WebCisplatin Foscarnet Aminoglycosides: Laxatives/enemas Sodium polystyrene sulfonate: ... Renal potassium wasting is indicated by a 24-hour urine potassium level exceeding 15 to 30 mEq per L.

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WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article … WebDec 13, 2024 · The electrolytes affected are primarily mineral ions, specifically potassium, calcium, magnesium, sodium, and chloride. Fundamentally, like Bartter’s syndrome, Gitelman syndrome is a salt wasting nephropathy. The symptoms and severity of the disorder can vary greatly from one person to another and can range from mild to severe.

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38(12 ... WebCisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle …

Webbular dysfunction with sodium, potassium, and magne-sium wasting. Most patients have a reversible decrease in glomerular filtration, but some have an irreversible de- ... Cisplatin is accumulated by peritubular uptake in both the proximal and … WebOct 5, 2014 · 1. Introduction. Cisplatin (CAS No. 15663-27-1, MF-Cl 2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry.It is a white or deep yellow to yellow-orange crystalline powder at room temperature. It is slightly soluble in water and soluble …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin …

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … ipl 2023 csk playersWebMar 1, 2024 · cisplatin cyclosporine duloxetine lithium methotrexate methylphenidate NSAIDs, such as diclofenac, ibuprofen, or indomethacin sucralfate other medications that lower potassium. People taking oral medications for diabetes may need to talk to their doctor about adjusting the dose of their medicine. ipl 2023 dc matchesWebRefractory Potassium Repletion due to Cisplatin-Induced Magnesium Depletion JAMA Internal Medicine JAMA Network • Cisplatin is a common cause of hypomagnesemia … orangeville wind farmWebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. orangeville wind farm nyWebJan 12, 2024 · A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin … orangeville white pagesWebNational Center for Biotechnology Information ipl 2023 chennai matchesWebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85 orangeville womens soccer