WebSep 8, 2024 · method in all functions was biweight midcorrelation (bicor) (maxPOutliers = 0.05) because of its robustness (Langfelder and Horvath, 2012). The power value of our. scale-free topology was 3. WebBiweight midcorrelation is considered to be a good alternative to Pearson correlation since it is more robust to outliers. In this paper, we introduce to use Biweight Midcorrelation to measure ‘similarity’ between gene expression profiles, and provide a new approach for gene differential coexpression analysis. The results show that the new ...
Frontiers Batch correction and harmonization of –Omics datasets …
WebIn statistics, biweight midcorrelation (also called bicor) is a measure of similarity between samples. It is median -based, rather than mean -based, thus is less sensitive to outliers, and can be a robust alternative to other similarity metrics, such as Pearson correlation or … WebThe functions cor and bicor for fast Pearson and biweight midcorrelation, respectively, are part of the updated, freely available R package WGCNA.The hierarchical clustering … rcvs second opinion
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WebJan 1, 2011 · The WGCNA function bicor implements a version of the biweight midcorrelation (see Sect. 5.1.3), which we have found to work very well for gene expression data. In the following, we illustrate our theoretical derivations using the yeast gene co-expression network. WebIn addition, WGCNA was used to calculate the weight value between two genes using the biweight midcorrelation method (bicor(A,B)). All gene pairs with a weight value >0.05 were retained. Amongst the four groups, the top 80 regulators (TFs and ncRNAs) were determined by selecting the highest weight values for each CYP3A , and these were … WebAug 29, 2014 · In this study, we evaluated the covariation assumption using three dependency measures (Pearson correlation coefficient, r; biweight midcorrelation, bicor; and mutual information based adjacency, AMI), five chromophores (organic C, Fe, clay, and sand contents, and geometric mean diameter), and seven non-chromophores (pH, … rcvs rvn record of traininig